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3,4-Methylenedioxymethcathinone (methylone) is a designer drug of the phenethylamine class. Methylone is a synthetic cathinone with substantial chemical, structural, and pharmacological similarities to 3,4 methylenedioxymethamphetamine (MDMA, ecstasy). Animal studies indicate that methylone has MDMA-like and (+)-amphetamine-like behavioral effects. When combined with mephedrone, a controlled schedule I substance, the combination is called “bubbles.”
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There are substantial pharmacological similarities between methylone and MDMA. Methylone and MDMA, similar to cocaine and methamphetamine, inhibit in vitro the neuronal reuptake of the monoamines dopamine and serotonin and increase concentrations of these monoamines in the synaptic cleft. Similar to methamphetamine, methylone and MDMA also increase, in vitro, the neuronal release of these monoamines. An increase in monoamine concentrations in the central nervous system is thought to be involved in the pharmacological effects of these substances. Methylone also resembles MDMA in drug discrimination assays.
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Furthermore, methylone, similar to MDMA, does not substitute for 4-methyl-2,5-dimethoxyamphetamine (DOM), a schedule I hallucinogen, in rats trained to discriminate DOM from saline. Because of the structural and pharmacological similarities between methylone and MDMA, the psychoactive effects, adverse health risks, and signs of intoxication resulting from methylone abuse are likely to be similar to those of MDMA. Several chat rooms discussed pleasant and positive effects of methylone when used for recreational purpose.
User Population:
Methylone, like other synthetic cathinones, is a recreational drug that emerged on the United States’ illicit drug market in 2009. It is perceived as being a ‘legal’ alternative to drugs of abuse like MDMA, methamphetamine, and cocaine. Evidence indicates that youths and young adults are the primary users of synthetic cathinone substances which include methylone. However, older adults also have been identified as users of these substances. Buy Methylone MDMA Online
